Hepatitis has been a significant disease of humanity. The history of the identification of causative viruses is one of the fascinating scientific adventures of this half-century. Individualization of different types of hepatitis only developed after world war two.
Their association has been associated with milestones which transformed medicine and public health.
The evolution of HBV brought the first ever vaccine not made by tissue culture but initially right from plasma and soon the first vaccine designed by genetic engineering.
HBV vaccine determined to be the first “anti-cancer” vaccine by inhibiting hepatocellular carcinoma and practically annihilating it from childhood in Taiwan. Strong vaccines also became available for HAV and more newly HEV.
The discovery of HCV in 1989 started a new era since it was the first virus was recognized by a direct molecular method.
Two billion people are infected with HBV, and 350 million are chronic transmitters of the virus. The surprising effectiveness of HBV vaccination was best illustrated in Taiwan and Singapore wherein less than 2 decades HBs Ag transports dropped from 9,1% to 2,7% and HCC from 27% to 17%.
The successful evolution of nucleus(t)ides analogs make it now reasonable to fully control disease progression with a daily pill long-term therapy.
The development in HCV therapy has been even more dramatic, and strong treatment jumped from 6 % with interferon alone in the year 1986 to more than 80% in 2013 with triple combination therapies. Especially chronic hepatitis C is the only chronic illness which is curable.
It will be soon likely to eradicate HCV infection with, an all oral, daily one pill (containing several molecules) for 3 to 6 months which will preserve over 90% of patients.
This unprecedented therapeutic victory advantaging hundred millions of people meet the triumphs over smallpox, polio, and tuberculosis. The next ten years should undoubtedly witness a cure or full control over all forms of acute and prolonged hepatitis.
The history of the development of hepatitis causes is one of the fascinating scientific adventures of the last 50 years. Their identification has been associated with significant cognitive milestones and breakthroughs which revolutionized medicine and public health.
The evolution of HBV started the process by bringing the hepatitis B vaccine, the first ever vaccine not made by tissue culture but directly from plasma. This unique achievement was soon replaced by a new leap to become the first vaccine produced by genetic engineering.
The implementation of the HBV vaccine determined to be the first ‘anti-cancer’ vaccine by inhibiting hepatocellular carcinoma and practically destroying it from childhood in Taiwan.
Since then universal hepatitis vaccine has been adopted by most of the nations. The development of HCV in 1989 opened a new era since it was the first virus which was acknowledged by a direct molecular approach, without tissue culture, electron microscopy or serology. Countless new infections have been detected this way since.
Remarkably, HCV explained most of post-transfusion, intravenous drug users and nosocomial hepatitis and proved to be the first cause of chronic liver disorders, cirrhosis, transplantation, and HCC in western and several developing countries.
The development of HBV made it possible to define the pathogenesis of polyarteritis nodosa and the HCV the etiology of cryoglobulinemia and to unravel a link among HCV and non-Hodgkin lymphoma but also with autoimmunity as well as lipidoglucidic changes effective for diabetes type II.
As often with scientific ventures, this hepatitis discovery saga now developing towards full, blessed achievement was a mixture of intellectual thinking, teamwork, rivalry, and serendipity.
You believe this is a history of hepatitis, but let’s do some math. What makes Hepato meaning “liver” plus tropic meaning “serious and replicating in the liver” plus DNA (HBV genome) level?
That’s right, boys and girls, we get the name of the condition most damaging to what ancient Mesopotamian cities held the seat of life–the liver.
The manifestations of liver disorders such as hepatitis B added jaundice, described by
Hippocrates and found to be contagious as early as the 8th century.
By 1885, hepatitis was seen to be transmittable within blood transfusions and syringes when diseases of jaundice broke out during the wars of the 17th-19th centuries. While World War II, among 1939-1945, a series of outbreaks occurred after treatment for measles and yellow fever, implying additional that the virus was blood-borne.
The implementation of the HBV vaccine determined to be the first ‘anti-cancer’ vaccine by inhibiting hepatocellular carcinoma and practically destroying it from childhood in Taiwan.
Since then universal hepatitis vaccine has been adopted by most of the nations. The development of HCV in 1989 opened a new era since it was the first virus which was acknowledged by a direct molecular approach, without tissue culture, electron microscopy or serology. Countless new infections have been detected this way since.
Remarkably, HCV explained most of post-transfusion, intravenous drug users and nosocomial hepatitis and proved to be the first cause of chronic liver disorders, cirrhosis, transplantation, and HCC in western and several developing countries.
The development of HBV made it possible to define the pathogenesis of polyarteritis nodosa and the HCV the etiology of cryoglobulinemia and to unravel a link among HCV and non-Hodgkin lymphoma but also with autoimmunity as well as lipidoglucidic changes effective for diabetes type II.
As often with scientific ventures, this hepatitis discovery saga now developing towards full, blessed achievement was a mixture of intellectual thinking, teamwork, rivalry, and serendipity.
You believe this is a history of hepatitis, but let’s do some math. What makes Hepato meaning “liver” plus tropic meaning “serious and replicating in the liver” plus DNA (HBV genome) level?
That’s right, boys and girls, we get the name of the condition most damaging to what ancient Mesopotamian cities held the seat of life–the liver.
The manifestations of liver disorders such as hepatitis B added jaundice, described by
Hippocrates and found to be contagious as early as the 8th century.
By 1885, hepatitis was seen to be transmittable within blood transfusions and syringes when diseases of jaundice broke out during the wars of the 17th-19th centuries. While World War II, among 1939-1945, a series of outbreaks occurred after treatment for measles and yellow fever, implying additional that the virus was blood-borne.
What Is The History Of Hepatitis?
- 8th Century: Dangerous Nature of HBV recommended.
- 17th-19th Centuries: Flashes of epidemics of jaundice in military and civilian communities during wars.
- 1883: Lurman describes outbreaks of serum hepatitis following vaccination of dockers.
- 1908: McDonald postulates that a virus causes infectious jaundice.
- 1939-1945: WWII-A series of outbreaks after vaccination for measles and yellow fever.
- 1947: MacCallum groups viral hepatitis into two types- Viral hepatitis A—> Infectious hepatitis and Viral hepatitis B—> Serum hepatitis.
- 1965: Blumberg explores Australia antigen (HBsAg) in aborigines and reveals the presence of antigen at a large rate in patients with leukaemia and children with Down’s syndrome.
- 1970: Dane recognizes the Dane particle (complete HBV particle).
- 1972: Discovers HBeAg.
- 1973: Feinstone and Purcell recognize HAV.
- 1977: Rizzetto describes delta antigen HDV.
- 1983: Restoration of HEV.
- 1988: Chiron combination (Choo, Kuo, Houghton) connects and recognizes HCV.
- 1995: Abbot association reports GB Virus-C (GBV-C) and Genelabs group records in the year 1996 hepatitis G virus (HGV)—GBV-C=HGV.
- 1996: Chang’s combination at NTUH reports in JAMA the successful inhibition of HBV infection by nation-wide protection on newborn babies launched in 1984 in Taiwan.
- 1997: Chang’s group at NTUH reports in NEJM a decrease in the yearly incidence rate of hepatocellular carcinoma in children ascribed to nation-wide protection against HBV on newborn babies began in 1984 in Taiwan.
What Is Hepatitis? – Types, Symptoms, Causes And Treatments
Hepatitis relates to an inflammatory condition of the liver. A viral infection commonly causes it, but there are other possible hepatitis causes.
These involve autoimmune hepatitis and hepatitis that occurs as a secondary effect of medications, drugs, toxins, and alcohol. Autoimmune hepatitis is an ailment that happens when your body makes antibodies toward your liver tissue. The above link takes you to know about hepatitis.
Why Hepstan Is Important For Your Liver Health?
Hepatitis is a disease that can cause serious harm to the body. INLIFE Hepstan Protein Powder contains the goodness of various herbs that can control this condition. To know more about inlife hepstan powder you can click on the link.What Are The Home Remedies For Hepatitis?
Hepatitis is an example of how a timely diagnosis, the discovery of the virus, evaluation of the necessary for treatment, effective oral drugs to manage the infection and preventing it from spreading can all be achieved effectively. If you want to know more about home remedies you can click the link which takes you for detailed information.
Hepatitis Diet: Why It Is Important?
Hepatitis is a contagious disorder of the liver, results from infection. Diet for hepatitis b plays a crucial role in keeping health in someone with Hepatitis.
Taking the required) amount of healthy foods and following the above links is key. Focus on getting as many fresh, whole foods rich as possible on a regular basis – and your body will thank you.
Let me know your thoughts how this all the above links helped you.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373556/
http://www.hepb.org/prevention-and-diagnosis/vaccination/history-of-hepatitis-b-vaccine/
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